There is a subset of DMARDs called biologic response modifiers . These drugs target specific parts of the immune system that trigger inflammation. One might target and block TNF inhibitors or the activation of T cells, which all plays a role in causing inflammation in the joints. By blocking specific steps in the process, these drugs prevent the entire immune response from being wiped out and vulnerable at once. This greatly reduces the risk of infection. Biologic agents are typically prescribed along with other medications to effectively fight RA symptoms.
A nurse or assistant mixes the powdered form of the Remicade with sterile water. The solution is injected into a large bag of sterile clear water for the infusion. Tubing is connected to the bag and the bag is attached atop an IV pole. The nurse then applies a tourniquet over an arm that has a visible vein. The vein is rubbed with alcohol and a fine needle catheter is inserted into the vein. (A catheter is a plastic tube with an attachment on one end into which tubing can be attached. This poke into the vein to insert the catheter is very similar to the feeling of having blood drawn.)
The recommendations in this guidance represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, health professionals are expected to take this guidance fully into account, alongside the individual needs, preferences and values of their patients. The application of the recommendations in this guidance is at the discretion of health professionals and their individual patients and do not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.