I do not believe that women should be excluded from the use of D Aspartic Acid. Even though there are no studies using women to test the affects of DAA it stands to logical thinking that the testosterone would be of a small amount. If DAA stimulates the pituitary gland to release luteinizing hormone in men which would stimulate their leydig cells to produce testosterone then DAA would stimulate the release of luteinizing hormone in women to stimulate the ovaries to produce testosterone as well as estradiol, estrone, estriol and progesterone meaning that testosterone would not be exclusive in women. Therefore women should be able to use this supplement but have to watch for symptoms of masculinization such as acne, facial hair and excess libido (which might be welcomed by their partners expecially if they are on birth control pills). Some women in the endeavor to build muscle may be willing to tolerate these side effects but since the pituitary-hypothalamus axis may limit the amount of hormones produce by their ovaries then many women may never experience these symptoms.
Testosterone is metabolised to various 17-keto steroids through two different pathways. The major active metabolites of testosterone are oestradiol and dihydrotestosterone (DHT). Testosterone is metabolised to DHT by steroid 5α reductase located in the skin, liver and the urogenital tract of the male. DHT binds with greater affinity to SHBG than does testosterone. In many tissues, the activity of testosterone depends on its reduction to DHT, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription and cellular changes related to androgen action. In reproductive tissues, DHT is further metabolised to 3- α and 3-β androstanediol.
Serious POME reactions, involving cough, urge to cough, dyspnea, hyperhidrosis, throat tightening, chest pain, dizziness, and syncope, have been reported to occur during or immediately after the injection of intramuscular testosterone undecanoate 1000 mg (4 mL). The majority of these events lasted a few minutes and resolved with supportive measures; however, some lasted up to several hours and some required emergency care and/or hospitalization. To minimize the risk of intravascular injection of AVEED ® , care should be taken to inject the preparation deeply into the gluteal muscle, being sure to follow the recommended procedure for intramuscular administration.