45) A man has been told that he is not synthesizing enough follicle-stimulating hormone (FSH),
and for this reason he may be unable to father a child. Choose the correct statement to explain
A) FSH stimulates estrogen secretion by ovarian cells; therefore it is not synthesized by
B) The physician is wronga hormone made in the adenohypophysis could not influence
C) FSH stimulates sperm production in the testes.
D) The man must be producing progesterone, which inhibits the synthesis of FSH.
Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.