Diagnosis Index entries containing back-references to :
While contraction is usually observed at the hand (Dupuytren's contraction), it is not typical for Ledderhose disease though it might happen. Development of cords seems to be less dominant for Ledderhose. Possibly weight and continuous exercise keep feet and toes straight or the Ledderhose nodules reside in a more static area and are thus subject to less pulling forces than the nodule's in the hand. Thus therapies to straighten toes again are less important for Ledderhose disease, the focus is more on reducing the size of the nodules, reducing pain and inflammation, and maintaining the ability to walk. Therefore therapies for Ledderhose and Dupuytren's are probably as similar as foot and hand: similar, but not the same.
The most common side effect reported with Transdermal Verapamil 15% Gel, affecting 3-5% of Peyronie's disease patients, is varying degrees of skin irritation. Some patients using the medication for the first time may experience mild itching/irritation during the first few days of treatment. This is normal and usually resolves within 3-4 days. Other patients may experience more severe contact dermatitis, including itching, burning, redness, or swelling. More persistent or severe irritation can usually be treated with topical corticosteroids. Based on the individual symptoms, PDLabs will work with the patient and prescribing physician to determine the best course of treatment to resolve irritation.