Additional actions of amphetamine contribute to its ability to release dopamine from neurons, including action as an inhibitor of Monoa amine oxidase, an enzyme responsible for dopamine breakdown in the cytosol; an ability to enhance dopamine synthesis it is presumed via actions on the enzyme Tyrosine hydroxylase, which synthesizes the dopamine precursor L DOPA; and some blockade of the DAT, an action that amphetamine shares with Cocaine. Due to the combination of these actions and its long half-life, amphetamine can release far more dopamine than can cocaine or other addictive drugs.
Propofol has probably the commonly used intravenous anesthetic and is most frequently used for the induction of anesthesia. Like most intravenous anesthetics, Propofol works by increasing GABA-mediated inhibatory tone in the CNS. Propofol decreases the rate of dissociation of the GABA from the receptor, thereby increasing the duration of the GABA-activated opening of the chloride channel with resulting hyperpolarization of cell membranes. At supraclinical concentrations, it may directly activate the receptor’s chloride channel.