Hidroxiesteroide deshidrogenasa

If the enzyme encoded by HSD11 is not responsible for 11β-hydroxysteroid dehydrogenase activity in the distal renal tubule, what then is its physiological function? This enzyme is present at very high levels in human liver, the main site of cortisone reduction, so it may function primarily as a reductase in vivo . Because HSD11 is widely expressed, it has also been suggested that the encoded enzyme functions to protect the glucocorticoid (Type II) receptor in various tissues from excessive concentrations of cortisol ( Whorwood et al ., 1992, 1993 ).

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This entry describes 2 <p> This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p> <a href='/help/alternative_products' target='_top'> More...</a> </p> isoforms i produced by alternative splicing . Align Add to basket Added to basket

This gene encodes a member of the aldo/keto reductase superfamily , which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone , a toxic organochlorine pesticide, to chlordecone alcohol in liver . This gene shares high sequence identity with three other gene members and is clustered with those three genes at 10p15-p14 on chromosome 10 . [6]

Hidroxiesteroide deshidrogenasa

hidroxiesteroide deshidrogenasa

This gene encodes a member of the aldo/keto reductase superfamily , which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone , a toxic organochlorine pesticide, to chlordecone alcohol in liver . This gene shares high sequence identity with three other gene members and is clustered with those three genes at 10p15-p14 on chromosome 10 . [6]

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