After the Kefauver Harris Amendment was passed in 1962, the . FDA began the DESI review process to ensure the safety and efficacy of drugs approved under the more lenient pre-1962 standards, including Dianabol.  In 1965, the FDA pressured CIBA to further document its legitimate medical uses, and re-approved the drug for treating post-menopausal osteoporosis and pituitary-deficient dwarfism .  After CIBA's patent exclusivity period lapsed, other manufacturers began to market generic metandienone in the .
Now, I know that’s a lot of information to take in, and it is largely conceptual. But, I hope this helps you understand what autoregulation is and isn’t as well as some of the fundamentals of and research on the repetitions in reserve-based RPE scale. If you are intrigued and would like a more practical tutorial of how it can be implemented within a programming strategy, I would highly recommend Dr. Zourdos recent article on load progression, which includes how to use RPE for this purpose. If you really want to dive in, consider a subscription to MASS where we do in-depth videos on how to program and autoregulate training.